7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
P-Anisyl Acetate
Molecular Formula
C10H12O3
Molecular Weight
180.20 g/mol
Category
fragrance
Bottom Line: P-Anisyl Acetate is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have allergies to similar compounds
✕ Avoid If:
- you have a known allergy to anisole derivatives
- you are using on broken skin
- you experience irritation or allergic reactions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H12O3 |
| Molecular Weight | 180.20 g/mol |
| Melting Point | 84.0°C |
| Boiling Point | 137.0°C |
| Solubility | miscible at room temperature (in ethanol) |
| Log P | 1.9 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics, but patch test recommended.
Food
Flavoring agents, baked goods. Used as a flavoring agent; ensure low concentration.
Pharmaceutical
Topical creams, ointments. Used in formulations; monitor for skin reactions.
Supplement
Dietary supplements. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
P-Anisyl Acetate is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of P-Anisyl Acetate may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: Moderate
Eye contact with P-Anisyl Acetate may cause irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- elderly — Generally well tolerated; monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for cosmetic ingredients. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Elderly individuals may have varying sensitivities. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
P-Anisyl Acetate is evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2017) |
| Sensitization | not sensitizing | Human repeated insult patch test | No sensitization observed | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
P-Anisyl Acetate is evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in food applications.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of P-Anisyl Acetate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on P-Anisyl Acetate
Year: 2018
Conclusion: Considered safe as a food flavoring agent.
View Full Report →
SCCS
Report: SCCS Opinion on P-Anisyl Acetate
Year: 2017
Conclusion: Safe for use in cosmetic products.
View Full Report →
Regulatory Status
Global
P-Anisyl Acetate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Yes, it is considered safe as a flavoring agent in food at regulated concentrations.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:31:17.116892Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.