6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
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Solvent · Fragrance Ingredient · Emollient · Stabilizer
Methyl Octine Carbonate
Molecular Formula
C10H16O2
Molecular Weight
168.23 g/mol
Category
Chemical Compound
Bottom Line: Methyl Octine Carbonate is generally considered safe for use in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other fragrances
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on open wounds or irritated skin
- Ingesting in large amounts
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H16O2 |
| Molecular Weight | 168.23 g/mol |
| Boiling Point | 121.0°C |
| Solubility | Soluble (in ethanol) |
| Log P | 3.7 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation to avoid skin irritation.
Food
Flavoring agents, beverages. Generally safe in food applications at low concentrations.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for use in medications.
Household
Cleaning products, air fresheners. Ensure good ventilation when using household products.
Supplement
Dietary supplements. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Methyl Octine Carbonate is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause gastrointestinal irritation; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may lead to respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to potential for adverse reactions.
- pregnant — Caution advised due to limited safety data.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally safe, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may apply. |
Toxicology Data
3 Endpoints
Methyl Octine Carbonate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methyl Octine Carbonate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetics.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methyl Octine Carbonate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Methyl Octine Carbonate
Year: 2018
Conclusion: Considered safe for use in food flavoring.
View Full Report →
SCCS
Report: Opinion on Methyl Octine Carbonate
Year: 2019
Conclusion: Safe for use in cosmetic products.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 173; maximum: (b) 0.002% when used alone When present in combination with methyl heptine carbonate, the combined level in the finished product should not exceed 0.01% (of which methyl octine carbonate should not be more than 0.002%); applies to: (a) Oral products (b) Others products Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 173)
Annex III entry 173; maximum: (b) 0.002% when used alone When present in combination with methyl heptine carbonate, the combined level in the finished product should not exceed 0.01% (of which methyl octine carbonate should not be more than 0.002%); applies to: (a) Oral products (b) Others products
US
FDAPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, it is safe for skin use in cosmetics, but individuals with sensitive skin should exercise caution.
Yes, it is considered safe for use in food flavoring at low concentrations.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:00:03.736330Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:31:55.450152+00:00 | 6.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.