6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · flavoring agent · aromatic compound · stabilizer
(1s,2s,3s,5r)-2,6,6-Trimethylspiro[Bicyclo[3.1.1]Heptane-3,4'-Cyclohex-2-Ene]-1'-One
Molecular Formula
C15H22O
Molecular Weight
218.33 g/mol
Category
fragrance compound
Bottom Line: Generally regarded as safe in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Ingested as part of food flavoring within regulatory limits
- Not applied to broken or irritated skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using multiple products containing fragrances
✕ Avoid If:
- You have a known allergy to fragrance compounds
- You experience irritation or adverse reactions
- Using on children without prior testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H22O |
| Molecular Weight | 218.33 g/mol |
| Log P | 3.8 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe when used as a food flavoring.
Pharmaceutical
Topical creams, medicated ointments. Consult a healthcare provider for use in medications.
Supplement
Dietary supplements, nutraceuticals. Use under guidance, especially if sensitive.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited safety data; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally low to moderate risk; monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Insufficient Data | Insufficient data on effects during breastfeeding; caution is warranted. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities; monitor closely. |
Toxicology Data
3 Endpoints
Research indicates moderate safety for use in cosmetics and food, though some individuals may react.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | N/A | Insufficient data for acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | Non-irritating | Human patch test | Low potential for skin irritation | SCCS Opinion (2021) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitization in sensitive individuals | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates moderate safety for use in cosmetics and food, though some individuals may react.
- Widely used in various consumer products
- Potential for skin irritation in sensitive individuals
- Regulatory assessments support its safe use
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2021
Conclusion: Safe for use in cosmetics with specified limits.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2019
Conclusion: Considered safe for use in food flavoring within established limits.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Use within specified limits
UK
UK GovernmentPERMITTED
Use within specified limits
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin may experience irritation.
Yes, it is permitted as a flavoring agent within regulatory limits.
Discontinue use immediately and consult a healthcare professional if needed.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:42:12.725272Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.