10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · solvent · skin conditioning agent · fragrance ingredient
Dimethylcyclohexylethoxy Isobutylpropanoate
Molecular Formula
C17H32O3
Molecular Weight
284.4 g/mol
Category
chemical compound
Bottom Line: Dimethylcyclohexylethoxy Isobutylpropanoate is generally considered safe for use in cosmetics and pharmaceuticals, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar ingredients
- You are pregnant or nursing
✕ Avoid If:
- You have known allergies to similar compounds
- You experience irritation or adverse reactions
- Using on children without consulting a physician
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C17H32O3 |
| Molecular Weight | 284.4 g/mol |
| Log P | 4.5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe in cosmetics, but patch test recommended.
Pharmaceutical
Topical ointments, transdermal patches. Use as directed; consult a doctor for concerns.
Food
Flavoring agents, food additives. Generally recognized as safe in food applications.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dimethylcyclohexylethoxy Isobutylpropanoate is generally well tolerated on skin.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks; limited data on long-term effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but should be minimized.
ocular
ocular
Risk Level: High
Eye contact may cause irritation; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally safe but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; monitor for any adverse reactions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution advised. |
| infants_children | High | Higher sensitivity in young children; avoid use if possible. |
| breastfeeding | Low to Moderate | Limited data on transfer through milk; use cautiously. |
| elderly | Low | Generally well tolerated; monitor for sensitivity. |
Toxicology Data
3 Endpoints
Dimethylcyclohexylethoxy Isobutylpropanoate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2021) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Dimethylcyclohexylethoxy Isobutylpropanoate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant irritation reported.
- Limited long-term data available.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Dimethylcyclohexylethoxy Isobutylpropanoate
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of food additives
Year: 2020
Conclusion: Considered safe for use in food applications.
View Full Report →
FDA
Report: Regulatory Status of Dimethylcyclohexylethoxy Isobutylpropanoate
Year: 2022
Conclusion: Permitted for use in cosmetics and food under specific conditions.
View Full Report →
Regulatory Status
Global
Dimethylcyclohexylethoxy Isobutylpropanoate is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Consult your healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:18:08.817948Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.