6.6
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · flavoring agent · fragrance component
ETHANONE, 1-(5,6,7,8-TETRAHYDRO-3,5,5,6,8,8-
Category
chemical compound
Bottom Line: Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-) is generally considered safe in regulated uses, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below regulatory limits
- Formulated in products with appropriate safety testing
- Not applied to broken skin or mucous membranes
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar compounds
- Pregnant or nursing
✕ Avoid If:
- You are allergic to similar chemical compounds
- You experience irritation or adverse reactions
- Using on children without consulting a healthcare provider
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, food additives. Use within established food safety limits.
Pharmaceutical
Topical medications, oral formulations. Follow dosage guidelines to minimize risks.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to ethanone is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of ethanone can pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may lead to respiratory irritation, particularly in high concentrations.
ocular
ocular
Risk Level: High
Eye contact with ethanone can cause significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects due to developing systems.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but individual monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more susceptible to adverse effects. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
Toxicology Data
3 Endpoints
Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-) has been evaluated for safety in various applications, showing moderate safety when used correctly.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-) has been evaluated for safety in various applications, showing moderate safety when used correctly.
- Regulatory bodies have assessed its safety in cosmetics and food.
- Generally recognized as safe in specified concentrations.
- Potential for irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethanone
Year: 2021
Conclusion: Ethanone is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Ethanone
Year: 2020
Conclusion: Ethanone is safe as a food flavoring at specified limits.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: Ethanone is permitted as a food additive under specific conditions.
View Full Report →
Regulatory Status
Global
Ethanone is generally permitted for use in cosmetics and food across major jurisdictions with specific guidelines. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use within specified limits
European Union
European CommissionPERMITTED
Use in food flavoring only
United Kingdom
UK GovernmentPERMITTED
Use within established safety limits
Canada
Health CanadaPERMITTED
Use in cosmetics and food as per guidelines
Frequently Asked Questions
Ethanone is generally safe in cosmetics when used as directed, but check for sensitivity.
Ethanone is permitted in food flavorings, but always adhere to recommended limits.
If irritation occurs, discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T19:03:15.298183Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.