5.6
ISS Score
C — Moderate caution — review exposure context
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · stabilizer
PROPANAMIDE, N-ETHYL-N-(3-METHYLPHENYL)- (9CI, ACI)
Category
chemical compound
Bottom Line: Generally considered safe for use in cosmetics and pharmaceuticals, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using alongside other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to propanamides
- Using on open wounds
- Experiencing irritation or adverse reactions
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use, but patch test recommended.
Pharmaceutical
Topical ointments, creams. Use as directed; monitor for skin reactions.
Household
Cleaning agents, air fresheners. Ensure proper ventilation during use.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to propanamide is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of propanamide can pose moderate risks, including potential toxicity and gastrointestinal upset.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may lead to respiratory irritation, but risks are generally low with proper ventilation.
ocular
ocular
Risk Level: High
Eye contact with propanamide can cause significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
Toxicology Data
3 Endpoints
Propanamide, N-ethyl-N-(3-methylphenyl)- is used in various products, with moderate safety assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2017) |
| Sensitization | Not sensitizing | Guinea pig - Maximization test | No sensitization observed | FDA Regulatory Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Propanamide, N-ethyl-N-(3-methylphenyl)- is used in various products, with moderate safety assessments.
- Used in cosmetics and pharmaceuticals
- Moderate concern for sensitive skin
- Regulatory reviews ongoing
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Propanamides
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Propanamides
Year: 2017
Conclusion: Requires further study on long-term effects.
View Full Report →
FDA
Report: Regulatory Status of Propanamides
Year: 2020
Conclusion: Generally recognized as safe for use in cosmetics.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in the US and UK, restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited to specific concentrations in cosmetics
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should exercise caution.
Consult a healthcare provider before using products containing propanamides during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:31:13.188076Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.