4.6
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aromatic compound · solvent · flavoring agent
BENZENEPROPANAL, 4-(1,1-DIMETHYLETHYL)-
Category
fragrance
Bottom Line: Generally regarded as safe in cosmetics and household products, though caution is advised in food applications.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- concentration is within regulatory limits
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in food products for consumption
- exposed to high concentrations in household products
✕ Avoid If:
- you are pregnant or nursing
- you have a known allergy to similar compounds
- using in products for children
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, beverages. Use with caution; regulatory status may vary.
Household
Cleaning products, air fresheners. Safe in household products if used as intended.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzenepropanal is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of benzenepropanal may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact with benzenepropanal can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to increased sensitivity to chemical exposures.
- pregnant — Potential for heightened sensitivity and effects on fetal development.
- sensitive_skin — Increased likelihood of irritation or allergic reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally tolerated, but individual sensitivities may vary.
- breastfeeding — Low to moderate risk, but caution is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults may tolerate benzenepropanal well, but individual sensitivities vary. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to chemicals, including benzenepropanal. |
| infants_children | High | Infants and children are more vulnerable to chemical exposures and may react more severely. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities; monitor for adverse reactions. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation or allergic reactions. |
Toxicology Data
3 Endpoints
Safety assessments indicate low concern for cosmetic use, but caution is advised for food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2018) |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2018) |
| Sensitization | Not sensitizing | Human clinical study | Low sensitization potential | CIR Safety Assessment (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Safety assessments indicate low concern for cosmetic use, but caution is advised for food applications.
- Low toxicity in cosmetic applications.
- Limited data on food safety.
- Regulatory reviews suggest cautious use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2018
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring
Year: 2020
Conclusion: Insufficient data to conclude on safety for food use.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: Not listed as a food additive; caution advised.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally safe in cosmetics but under review for food use. Switch to Detailed mode for full regulatory breakdown.
United States
FDANOT LISTED
Not approved as a food additive.
European Union
European CommissionUNDER REVIEW
Pending safety assessment for food use.
United Kingdom
UK GovernmentNOT LISTED
No specific regulations identified.
Canada
Health CanadaNOT LISTED
No specific regulations identified.
Frequently Asked Questions
Generally considered safe in cosmetics when used as directed, though individual sensitivities may vary.
Caution is advised; it is not approved as a food additive in the US and is under review in the EU.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:04:17.258010Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.