6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · emollient · plasticizer
Ethyl Trimethylcyclohexane Carboxylate
Molecular Formula
C12H22O2
Molecular Weight
198.30 g/mol
Category
chemical compound
Bottom Line: Ethyl Trimethylcyclohexane Carboxylate is generally considered safe for use in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in concentrations below 1%
- applied to intact skin
- used in well-formulated products
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have known allergies to similar compounds
- you experience irritation upon use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H22O2 |
| Molecular Weight | 198.30 g/mol |
| Log P | 3.8 |
Common Use Cases
5 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Used in low concentrations; check for allergies.
Pharmaceutical
Topical ointments, transdermal patches. Monitor for skin reactions; consult a doctor if unsure.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas; avoid ingestion.
Supplement
Dietary supplements, nutraceuticals. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Ethyl Trimethylcyclohexane Carboxylate is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but prolonged exposure may cause respiratory irritation.
ocular
ocular
Risk Level: Moderate
Eye contact may cause irritation; rinsing is recommended if contact occurs.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but individual responses may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate this ingredient with minimal risk. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
Ethyl Trimethylcyclohexane Carboxylate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2020) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethyl Trimethylcyclohexane Carboxylate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Generally recognized as safe in cosmetic formulations.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethyl Trimethylcyclohexane Carboxylate
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Ethyl Trimethylcyclohexane Carboxylate
Year: 2019
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: Permitted for use in food applications.
View Full Report →
Regulatory Status
Global
Ethyl Trimethylcyclohexane Carboxylate is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, yes, but patch testing is recommended for sensitive skin.
Yes, it is permitted as a food additive within specified limits.
Side effects are rare, but irritation may occur in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:42:40.453447Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.