6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · aroma enhancer · solvent · flavoring agent
1-(3-Methyl-1-Benzofuran-2-Yl)Ethanone
Molecular Formula
C11H10O2
Molecular Weight
174.20 g/mol
Category
fragrance compound
Bottom Line: Generally regarded as safe when used appropriately, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin or open wounds
- Used in well-ventilated areas to avoid inhalation
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- Using other products containing fragrances
✕ Avoid If:
- You have a known allergy to fragrance compounds
- You experience irritation or adverse reactions
- Using in high concentrations without proper dilution
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H10O2 |
| Molecular Weight | 174.20 g/mol |
| Log P | 2.7 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe in food applications at regulated levels.
Pharmaceutical
Topical creams, ointments. Monitor for skin reactions when used in formulations.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this substance is generally low risk, but irritation may occur in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential toxicity and gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Ocular exposure can lead to significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to potential toxic effects.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to potential toxic effects. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is warranted. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
1-(3-Methyl-1-Benzofuran-2-Yl)Ethanone is a fragrance compound with limited safety data.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitive individuals | SCCS Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-(3-Methyl-1-Benzofuran-2-Yl)Ethanone is a fragrance compound with limited safety data.
- Used in cosmetics and food flavoring
- Potential for skin sensitization
- Regulatory assessments vary by region
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe in cosmetics at low concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2019
Conclusion: Requires caution due to potential sensitization.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2020
Conclusion: Considered safe for use in food at specified levels.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food, with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Use limited to specific concentrations in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin may experience reactions.
Yes, it is permitted in food flavoring at regulated levels.
Discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:30:21.552317Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.