6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · solvent · stabilizer
(E)-3,3-Dimethyl-5-(2,2,3-Trimethylcyclopent-3-En-1-Yl)Pent-4-En-2-Ol
Molecular Formula
C15H26O
Molecular Weight
222.37 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe in cosmetics and food, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Formulated in products for intended use
- No known allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar ingredients
- Pregnant or nursing
✕ Avoid If:
- You experience irritation or allergic reactions
- Using on broken or damaged skin
- Under medical treatment for skin conditions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H26O |
| Molecular Weight | 222.37 g/mol |
| Log P | 3.8 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair products. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, food additives. Use in food is limited; check for allergies.
Pharmaceutical
Topical treatments, prescription creams. Consult a healthcare provider for use in medications.
Supplement
Dietary supplements, herbal products. Limited evidence for safety in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse effects due to sensitivity.
- pregnant — Limited safety data; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risks.
- breastfeeding — Use with caution; consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in children may lead to adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is warranted. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Limited safety data available; generally safe in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human patch test | Low sensitization potential | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited safety data available; generally safe in cosmetics and food.
- CIR supports its use in cosmetics.
- SCCS has no specific opinion on this ingredient.
- EFSA has limited data on food safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (E)-3,3-Dimethyl-5-(2,2,3-Trimethylcyclopent-3-En-1-Yl)Pent-4-En-2-Ol
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of food flavoring substances
Year: 2020
Conclusion: Insufficient data to conclude on safety in food applications.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2023
Conclusion: No specific regulations; generally recognized as safe.
View Full Report →
Regulatory Status
Global
Generally recognized as safe in the US; limited data in EU and Canada. Switch to Detailed mode for full regulatory breakdown.
United States
FDAGENERALLY RECOGNIZED AS SAFE
None
European Union
European CommissionNO SPECIFIC OPINION
None
United Kingdom
UK GovernmentNO SPECIFIC OPINION
None
Canada
Health CanadaNO SPECIFIC OPINION
None
Frequently Asked Questions
Generally safe for skin use in cosmetics, though individual reactions may vary.
Use with caution; perform a patch test to check for reactions.
Limited data on food safety; consult a healthcare provider for advice.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:24:38.016044Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.