9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
(2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol
Molecular Formula
C12H16O
Molecular Weight
176.25 g/mol
Category
chemical compound
Bottom Line: Generally, (2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol is considered safe for use in cosmetics and pharmaceuticals, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on open wounds or irritated skin
- You experience adverse reactions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H16O |
| Molecular Weight | 176.25 g/mol |
| Log P | 2.5 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Use in moderation and patch test for sensitivity.
Pharmaceutical
Topical ointments, creams. Consult a healthcare provider before use.
Supplement
Dietary supplements. Follow dosage recommendations carefully.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance may cause significant irritation or damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Research indicates (2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol is generally safe in cosmetics, though limited data exists for food use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2021) |
| Skin Irritation | Mild irritant | Human patch test | Low concern for irritation | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical study | Low concern for sensitization | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates (2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol is generally safe in cosmetics, though limited data exists for food use.
- Limited studies on human exposure
- Potential for skin irritation
- Regulatory reviews ongoing
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on (2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol
Year: 2020
Conclusion: Insufficient data to determine safety in food applications.
View Full Report →
FDA
Report: Regulatory Status of (2,5-Dimethyl-1,3-Dihydroinden-2-Yl)Methanol
Year: 2022
Conclusion: No specific regulations; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in the US and UK, under review in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further studies
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
None
Frequently Asked Questions
Generally considered safe in cosmetics at recommended concentrations, though patch testing is advised.
Caution is advised; patch test before full application to check for irritation.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:53:35.650181Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.