7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · emollient · stabilizer
Phenylacetaldehyde Glyceryl Cyclic Acetals
Molecular Formula
C11H14O3
Molecular Weight
194.23 g/mol
Category
Chemical Compound
Bottom Line: Phenylacetaldehyde Glyceryl Cyclic Acetals are generally considered safe in cosmetic and food applications, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H14O3 |
| Molecular Weight | 194.23 g/mol |
| Solubility | Miscible at room temperature (in ethanol) |
| Log P | 1.2 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical medications, oral formulations. Monitor for allergic reactions in sensitive individuals.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Phenylacetaldehyde Glyceryl Cyclic Acetals typically show low dermal irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may lead to moderate gastrointestinal discomfort based on available evidence.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is generally low risk but may cause mild respiratory irritation.
ocular
ocular
Risk Level: Low
Eye contact may cause mild irritation, but significant effects are unlikely.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited safety data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated; monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant adverse effects reported. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated; monitor for any adverse reactions. |
Toxicology Data
3 Endpoints
Phenylacetaldehyde Glyceryl Cyclic Acetals have been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | EFSA Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization Test | No sensitization observed | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Phenylacetaldehyde Glyceryl Cyclic Acetals have been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity reported.
- Generally safe in cosmetic formulations.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Phenylacetaldehyde Glyceryl Cyclic Acetals
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Phenylacetaldehyde Glyceryl Cyclic Acetals
Year: 2019
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
FDA
Report: Food Additive Status
Year: 2021
Conclusion: Generally recognized as safe when used in accordance with good manufacturing practices.
View Full Report →
Regulatory Status
Global
Phenylacetaldehyde Glyceryl Cyclic Acetals are generally permitted across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:41:03.191859Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.