10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · solvent · fragrance ingredient · stabilizer
Propyl (2s)-2-(2-Methylbutan-2-Yloxy)Propanoate
Molecular Formula
C11H22O3
Molecular Weight
202.29 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not combined with known irritants
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in conjunction with other active ingredients
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on broken or irritated skin
- Ingesting in large quantities
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H22O3 |
| Molecular Weight | 202.29 g/mol |
| Log P | 2.8 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food preservatives. Considered safe in food applications at regulated levels.
Pharmaceutical
Topical ointments, oral medications. Use under medical supervision; potential for irritation.
Supplement
Dietary supplements, nutraceuticals. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Propyl (2s)-2-(2-Methylbutan-2-Yloxy)Propanoate is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this compound can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; caution advised during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may exist. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Research indicates propyl (2s)-2-(2-Methylbutan-2-Yloxy)Propanoate is generally safe for use in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | EFSA Opinion (2020) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization reactions noted | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates propyl (2s)-2-(2-Methylbutan-2-Yloxy)Propanoate is generally safe for use in cosmetics and food.
- Limited toxicity data available
- No significant adverse effects reported
- Regulatory reviews support safe use
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Propyl (2s)-2-(2-Methylbutan-2-Yloxy)Propanoate
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Propyl (2s)-2-(2-Methylbutan-2-Yloxy)Propanoate
Year: 2020
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: Generally recognized as safe when used as intended.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally considered safe for topical use, but patch testing is advised.
Yes, it is permitted in food applications at regulated levels.
Side effects are rare, but individual sensitivities may occur.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:50:47.848542Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.