7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative · aromatic compound
Acetylcedrene
Molecular Formula
C17H26O
Molecular Weight
246.4 g/mol
Category
fragrance
Bottom Line: Acetylcedrene is generally considered safe in cosmetics and household products, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other fragrance products
✕ Avoid If:
- you have a known allergy to fragrances
- you experience irritation or allergic reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C17H26O |
| Molecular Weight | 246.4 g/mol |
| Log P | 4 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics, but patch test recommended.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to minimize inhalation risks.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider if unsure about use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Acetylcedrene is generally well tolerated on the skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Insufficient Data
Limited data on oral toxicity; ingestion should be avoided.
inhalation
inhalation
Risk Level: Moderate
Inhalation may cause respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; use with caution.
- sensitive_skin — Increased likelihood of skin irritation.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally safe but should be monitored.
- breastfeeding — Use with caution; limited data available.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited studies on safety during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity to chemicals; risk of irritation is significant. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low | Generally well tolerated, but monitor for skin reactions. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Acetylcedrene is a fragrance ingredient with moderate safety assessments supporting its use in cosmetics and household products.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Human repeated insult patch test | No sensitization observed | FDA Regulatory Status (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Acetylcedrene is a fragrance ingredient with moderate safety assessments supporting its use in cosmetics and household products.
- Commonly used in various cosmetic formulations.
- Generally recognized as safe in low concentrations.
- May cause allergic reactions in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Acetylcedrene
Year: 2015
Conclusion: Acetylcedrene is safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Acetylcedrene
Year: 2018
Conclusion: Acetylcedrene is safe for use in cosmetic products under the specified conditions.
View Full Report →
FDA
Report: Regulatory Status of Acetylcedrene
Year: 2020
Conclusion: Acetylcedrene is permitted for use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 327; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 327)
Annex III entry 327; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use
United States
FDAPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Though rare, some individuals may experience allergic reactions; discontinue use if irritation occurs.
Acetylcedrene is often found in perfumes, lotions, and household cleaning products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:55:58.730311Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:31:17.355895+00:00 | 7.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.