4.0
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane
Molecular Formula
C10H16
Molecular Weight
136.23 g/mol
Category
chemical compound
Bottom Line: 4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane is generally considered safe in cosmetics, though caution is advised based on concentration and usage.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- using on broken skin
- applying in large amounts
✕ Avoid If:
- you are pregnant or nursing
- you have a known allergy to similar compounds
- using on mucous membranes
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H16 |
| Molecular Weight | 136.23 g/mol |
| Log P | 3.1 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, hair styling products, body lotions. Use in moderation and avoid sensitive areas.
Pharmaceutical
Topical ointments, transdermal patches. Consult a healthcare provider before use.
Household
Cleaning agents, air fresheners. Ensure good ventilation when using.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, including potential toxicity and gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and potential damage, warranting caution.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for adverse reactions.
- pregnant — Limited data on safety during pregnancy; caution is advised.
- sensitive_skin — Increased likelihood of irritation and adverse reactions.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risk.
- elderly — Typically low to moderate risk, but monitoring is recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low to Moderate | Elderly may have increased sensitivity to chemicals. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Research indicates moderate safety for 4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane in cosmetics, with limited data on long-term effects.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Status (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates moderate safety for 4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane in cosmetics, with limited data on long-term effects.
- Generally safe in low concentrations.
- Potential irritant in high doses.
- Limited long-term safety data.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on 4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane
Year: 2022
Conclusion: Requires further investigation on sensitization potential.
View Full Report →
FDA
Report: Regulatory Status of 4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane
Year: 2023
Conclusion: No specific restrictions; safe for use in cosmetics.
View Full Report →
Regulatory Status
Global
4-Methylidene-1-Propan-2-Ylbicyclo[3.1.0]Hexane is permitted in the US and Canada, under review in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further studies
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe in low concentrations, but caution is advised for sensitive skin.
It is often found in facial creams, hair products, and some pharmaceuticals.
Potential side effects include irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:35:39.649123Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.