8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · odor masking agent · fixative · sensory enhancer
5,5,6-Trimethylbicyclohept-2-Ylcyclohexanol
Molecular Formula
C16H28O
Molecular Weight
236.39 g/mol
Category
fragrance
Bottom Line: 5,5,6-Trimethylbicyclohept-2-Ylcyclohexanol is generally considered safe in cosmetics, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic products
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using products containing multiple fragrances
- You are pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation upon use
- Using on children without prior testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H28O |
| Molecular Weight | 236.39 g/mol |
| Log P | 4.6 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents. Use in food is limited; check local regulations.
Pharmaceutical
Topical medications. Use with caution in sensitive formulations.
Household
Air fresheners, cleaning products. Ensure good ventilation when using household products.
Supplement
Flavoring agents in supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 5,5,6-Trimethylbicyclohept-2-Ylcyclohexanol is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited data on effects during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — May tolerate with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Insufficient Data | Insufficient data on safety during breastfeeding. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
5,5,6-Trimethylbicyclohept-2-Ylcyclohexanol has limited safety data, primarily used in fragrances.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2020) |
| Sensitization | Not sensitizing | Human patch test | Low sensitization potential | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
5,5,6-Trimethylbicyclohept-2-Ylcyclohexanol has limited safety data, primarily used in fragrances.
- Used mainly in cosmetic and fragrance products
- Limited toxicological data available
- Regulatory assessments are ongoing
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Generally safe for use in cosmetics at low concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2021
Conclusion: Requires further investigation for long-term safety.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2019
Conclusion: Insufficient data to assess safety in food applications.
View Full Report →
Regulatory Status
Global
5,5,6-Trimethylbicyclohept-2-Ylcyclohexanol is permitted in the US and Canada, under review in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further assessment
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation for some; patch testing is recommended before use.
Consult a healthcare provider before using products containing this ingredient.
Potential side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:40:51.562371Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.