9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
2-(6,6-Dimethyl-2-Bicyclo[3.1.1]Hept-2-Enyl)Ethyl Acetate
Molecular Formula
C13H20O2
Molecular Weight
208.30 g/mol
Category
fragrance
Bottom Line: Generally considered safe for use in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin
- Used in well-ventilated areas
- Not consumed in excessive amounts
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other fragrances or skin products
- You have a history of respiratory issues
✕ Avoid If:
- You are allergic to similar compounds
- You experience irritation upon use
- You are using it in food products for children
- You have a known sensitivity to fragrances
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H20O2 |
| Molecular Weight | 208.30 g/mol |
| Log P | 2.6 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation and patch test for sensitivity.
Food
Flavoring agents, beverages. Generally safe in food, but avoid excessive consumption.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this ingredient is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on exposure levels.
ocular
ocular
Risk Level: Low
Eye contact is generally low risk, but irritation may occur.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Potential for increased sensitivity during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Typically low risk, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure. |
| pregnant | Moderate | Pregnant individuals may be more sensitive to certain chemicals. |
| infants_children | High | Children's developing systems may react differently to exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
| elderly | Low | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
Safety assessments suggest low toxicity and minimal risk when used appropriately.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Safety assessments suggest low toxicity and minimal risk when used appropriately.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetics.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2018
Conclusion: Considered safe for use in food flavoring.
View Full Report →
SCCS
Report: SCCS Opinion on Fragrance Substances
Year: 2019
Conclusion: Low risk when used in cosmetics.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use in cosmetics, though patch testing is recommended.
Yes, it is permitted in food flavoring but should be used in moderation.
Some individuals may experience irritation or allergic reactions; use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:54:31.250420Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.