4.0
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aromatic compound · solvent · stabilizer
(3s,3as,5r)-3,8-Dimethyl-5-Prop-1-En-2-Yl-1,2,3,3a,4,5,6,7-Octahydroazulene
Molecular Formula
C15H24
Molecular Weight
204.35 g/mol
Category
fragrance
Bottom Line: Generally regarded as safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have allergies to fragrances
✕ Avoid If:
- you experience irritation or allergic reactions
- you are using on children under 3 years
- you have a known sensitivity to similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 g/mol |
| Log P | 4.6 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation to avoid potential skin irritation.
Food
Flavoring agents, beverages. Generally safe when used as a flavoring agent.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for use in medications.
Supplement
Dietary supplements. Use under guidance of a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally considered low risk based on available studies.
oral
oral
Risk Level: Moderate
Oral ingestion may pose moderate risks, particularly at higher doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally of very low risk, but irritation may occur.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects.
- pregnant — Increased sensitivity during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated by adults.
- elderly — Generally low risk but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure. |
| pregnant | Moderate | Pregnant individuals may have increased sensitivity to certain substances. |
| infants_children | High | Children may be more susceptible to adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk. |
| elderly | Low | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
Research indicates that this ingredient is generally safe for use in cosmetics and food, though individual reactions may occur.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | Not sensitizing | Human sensitization study | Low sensitization potential | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates that this ingredient is generally safe for use in cosmetics and food, though individual reactions may occur.
- Widely used in fragrance formulations.
- Low toxicity levels reported in studies.
- Regulatory assessments support its safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at typical concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Generally safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Considered safe for use in food flavoring.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin may experience irritation.
Yes, it is permitted as a flavoring agent in food products.
Some individuals may experience allergic reactions; patch testing is recommended.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:30:31.729127Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.