6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Fragrance ingredient · Flavoring agent · Solvent · Aromatic compound
1,4-Dimethyl-7-Prop-1-En-2-Yl-1,2,3,4,5,6,7,8-Octahydroazulene
Molecular Formula
C15H24
Molecular Weight
204.35 g/mol
Category
Fragrance
Bottom Line: 1,4-Dimethyl-7-Prop-1-En-2-Yl-1,2,3,4,5,6,7,8-Octahydroazulene is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Ingested as part of food flavoring within regulatory limits
- Not applied to broken skin or mucous membranes
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other products with potential irritants
✕ Avoid If:
- You have a known allergy to similar fragrance compounds
- You experience irritation or adverse reactions
- You are using it in high concentrations without proper guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 g/mol |
| Log P | 4.6 |
Common Use Cases
4 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, beverages. Safe for consumption in regulated amounts.
Pharmaceutical
Topical creams, ointments. Use with caution in sensitive formulations.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 1,4-Dimethyl-7-Prop-1-En-2-Yl-1,2,3,4,5,6,7,8-Octahydroazulene is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Very Low
Eye contact with this substance is associated with very low risk based on available evidence.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally low risk, but individual monitoring is recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Elderly individuals may have different sensitivities; monitor closely. |
Toxicology Data
3 Endpoints
1,4-Dimethyl-7-Prop-1-En-2-Yl-1,2,3,4,5,6,7,8-Octahydroazulene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | Not a skin irritant | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization observed | EFSA Opinion (2017) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1,4-Dimethyl-7-Prop-1-En-2-Yl-1,2,3,4,5,6,7,8-Octahydroazulene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies
- Generally recognized as safe in food applications
- Limited skin irritation potential in cosmetic use
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetic products within specified limits.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2017
Conclusion: Evaluated as safe for use in food flavoring at regulated levels.
View Full Report →
Regulatory Status
Global
1,4-Dimethyl-7-Prop-1-En-2-Yl-1,2,3,4,5,6,7,8-Octahydroazulene is permitted in major jurisdictions with no specific restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Yes, it is generally considered safe in cosmetics when used as directed.
It is typically safe to consume in regulated amounts as a food flavoring.
Some individuals may experience irritation or allergic reactions; use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:33:01.400100Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.