9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
1-Methoxy-4-Prop-1-Enylbenzene
Molecular Formula
C10H12O
Molecular Weight
148.20 g/mol
Category
aromatic compound
Bottom Line: 1-Methoxy-4-Prop-1-Enylbenzene is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- formulated in products for external use only
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in conjunction with other active ingredients
- consuming in large amounts
✕ Avoid If:
- pregnant or breastfeeding without consulting a doctor
- you have a known allergy to similar compounds
- using on open wounds or irritated skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H12O |
| Molecular Weight | 148.20 g/mol |
| Melting Point | 0.1507°C |
| Boiling Point | 234.0°C |
| Solubility | 1 ml in 2 ml 96% alcohol (in ethanol) |
| Log P | 3.3 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, lotions. Generally safe in cosmetic formulations when used appropriately.
Food
Flavoring agents, beverages. Use in food is regulated; ensure compliance with local guidelines.
Pharmaceutical
Topical medications, ointments. Consult a healthcare provider for medicinal use.
Supplement
Dietary supplements. Use with caution; consult a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
1-Methoxy-4-Prop-1-Enylbenzene is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of 1-Methoxy-4-Prop-1-Enylbenzene may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact with 1-Methoxy-4-Prop-1-Enylbenzene can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- sensitive_skin — Moderate risk; patch testing is recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Insufficient Data | Insufficient data on safety during breastfeeding. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
1-Methoxy-4-Prop-1-Enylbenzene has limited safety data, primarily used in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-Methoxy-4-Prop-1-Enylbenzene has limited safety data, primarily used in cosmetics and food.
- Used in various cosmetic and food products.
- Safety assessments indicate moderate concern in high concentrations.
- Regulatory reviews are ongoing in several jurisdictions.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 1-Methoxy-4-Prop-1-Enylbenzene
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on 1-Methoxy-4-Prop-1-Enylbenzene
Year: 2020
Conclusion: Considered safe as a food flavoring agent within specified limits.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: No specific regulations; generally recognized as safe in food.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 329; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 329)
Annex III entry 329; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use
United States
FDAGENERALLY RECOGNIZED AS SAFE
None
United Kingdom
UK GovernmentPERMITTED IN COSMETICS AND FOOD
Must comply with safety limits
Canada
Health CanadaPERMITTED IN COSMETICS
Must comply with safety limits
Frequently Asked Questions
Generally, yes, but it's best to check for individual sensitivities.
Typically safe in food, but moderation is advised.
Side effects are rare, but allergic reactions may occur in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:34:54.139030Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:31:13.440962+00:00 | 9.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.