6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · odor masking agent · solvent · stabilizer
(1s,2r,4r)-1,7,7-Trimethylbicyclo[2.2.1]Heptan-2-Ol
Molecular Formula
C10H18O
Molecular Weight
154.25 g/mol
Category
fragrance ingredient
Bottom Line: Generally regarded as safe when used in low concentrations, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in cosmetic formulations at recommended concentrations
- Ingested in food products within regulatory limits
- Applied to intact skin without prior irritation
⚠ Use with Awareness If:
- You have sensitive skin or known allergies
- Using in combination with other fragrance ingredients
- Pregnant or nursing, consult a healthcare provider
✕ Avoid If:
- You have a history of fragrance allergies
- Using on broken or irritated skin
- Ingesting in large amounts outside of food products
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H18O |
| Molecular Weight | 154.25 g/mol |
| Melting Point | 210.0°C |
| Boiling Point | 210.0°C |
| Log P | 2.7 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe when used within food safety regulations.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for use in sensitive formulations.
Supplement
Flavoring in dietary supplements. Ensure compliance with dietary supplement regulations.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally well tolerated with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation.
ocular
ocular
Risk Level: High
Eye contact may lead to significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to developing systems.
- pregnant — Limited safety data; potential risks to fetal development.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- breastfeeding — Generally low risk but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in younger populations; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Evidence suggests this ingredient is safe for use in cosmetics and food, though sensitivities may occur.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not applicable | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitive individuals | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Evidence suggests this ingredient is safe for use in cosmetics and food, though sensitivities may occur.
- Widely used in cosmetics and food products
- Regulatory bodies have assessed its safety
- Potential for allergic reactions in sensitive individuals
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetic products with restrictions
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2019
Conclusion: Safe for use in food flavoring within specified limits
View Full Report →
Regulatory Status
Global
Regulatory assessments indicate safe use in cosmetics and food under specified conditions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Use within SCCS guidelines
UK
UK GovernmentPERMITTED
Use within safety guidelines
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin may experience irritation.
Yes, it is permitted in food products within regulatory limits.
Discontinue use immediately and consult a healthcare professional if symptoms persist.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:41:16.025983Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.