5.0
ISS Score
C — Moderate caution — review exposure context
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aromatic compound · solvent · stabilizer
3,7,7-Trimethylbicyclo[4.1.0]Hept-3-Ene
Molecular Formula
C10H16
Molecular Weight
136.23 g/mol
Category
fragrance
Bottom Line: Generally regarded as safe in low concentrations, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- concentrations are kept low
- not applied to broken skin
- used in ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in products for children
- exposed to high concentrations
- using alongside other fragrances
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation upon use
- using in high concentrations without dilution
- applying to mucous membranes
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H16 |
| Molecular Weight | 136.23 g/mol |
| Log P | 2.8 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food additives. Generally safe in food applications at regulated levels.
Pharmaceutical
Topical medications, ointments. Monitor for allergic reactions in sensitive individuals.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using products.
Supplement
Aromatic oils, herbal blends. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 3,7,7-Trimethylbicyclo[4.1.0]Hept-3-Ene is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks due to limited toxicity data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but data is limited.
ocular
ocular
Risk Level: Insufficient Data
Safety data for ocular exposure is insufficient to determine risk levels.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children may have heightened sensitivity to chemical exposures.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated, but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
Toxicology Data
3 Endpoints
3,7,7-Trimethylbicyclo[4.1.0]Hept-3-Ene is used in various products, with moderate safety data available.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | non-sensitizing | Human clinical study | Low sensitization potential | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
3,7,7-Trimethylbicyclo[4.1.0]Hept-3-Ene is used in various products, with moderate safety data available.
- Used primarily in fragrances and cosmetics.
- Limited data on food safety.
- Regulatory assessments indicate low concern.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at low concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Safety concerns are low when used appropriately.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe in cosmetics at low concentrations, though some may experience irritation.
Yes, it is permitted in food at regulated levels, but check local guidelines.
Some individuals may experience allergic reactions; patch testing is recommended.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:22:52.561849Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.