7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · fixative · odor masking agent
Tetramethyl Acetyloctahydronaphthalenes
Molecular Formula
C16H26O
Molecular Weight
234.38 g/mol
Category
fragrance ingredient
Bottom Line: Tetramethyl Acetyloctahydronaphthalenes are generally considered safe in cosmetics and household products, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in well-formulated products
- applied to intact skin
- used in accordance with recommended concentrations
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- applying to broken or irritated skin
✕ Avoid If:
- you are pregnant or nursing
- you have a known fragrance allergy
- using in high concentrations without dilution
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H26O |
| Molecular Weight | 234.38 g/mol |
| Log P | 3.6 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation and patch test for sensitivities.
Household
Cleaning products, air fresheners. Ensure proper ventilation when using products.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for sensitive skin.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Tetramethyl Acetyloctahydronaphthalenes is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Tetramethyl Acetyloctahydronaphthalenes poses moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with Tetramethyl Acetyloctahydronaphthalenes can cause significant irritation and damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but individual responses may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no known severe reactions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Tetramethyl Acetyloctahydronaphthalenes are fragrance compounds with moderate safety profiles based on available assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity | — |
| Skin Irritation | Mildly irritating | Human patch test | Low concern for irritation in most users | CIR Safety Assessment (2015) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitization in sensitive individuals | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Tetramethyl Acetyloctahydronaphthalenes are fragrance compounds with moderate safety profiles based on available assessments.
- Used widely in cosmetics and household products.
- Moderate concern for skin irritation in sensitive individuals.
- Regulatory bodies have assessed safety with some restrictions.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Safety concerns noted for certain populations; use with caution.
View Full Report →
FDA
Report: Fragrance Ingredient Safety
Year: 2020
Conclusion: Generally recognized as safe when used as intended.
View Full Report →
Regulatory Status
Global
Tetramethyl Acetyloctahydronaphthalenes are permitted in the US and UK, with restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Use limited to certain concentrations in cosmetics.
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO_DATA
No specific regulations identified.
Frequently Asked Questions
They are synthetic fragrance compounds used in various products.
They may cause irritation in sensitive individuals; patch testing is recommended.
It is advisable to consult a healthcare provider before use during pregnancy.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:03:41.568587Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.