7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
antioxidant · preservative · fragrance ingredient · skin conditioning agent
2-Ethoxy-4-(Methoxymethyl)Phenol
Molecular Formula
C10H14O3
Molecular Weight
182.22 g/mol
Category
chemical compound
Bottom Line: 2-Ethoxy-4-(Methoxymethyl)Phenol is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive skin.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below 1%
- Formulated in products for external use only
- Not used on broken or irritated skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You experience irritation or allergic reactions
- Using on open wounds or mucous membranes
- Using in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H14O3 |
| Molecular Weight | 182.22 g/mol |
| Log P | 1.6 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Generally safe for topical use; avoid sensitive areas.
Pharmaceutical
Topical ointments, creams. Use as directed; monitor for skin reactions.
Household
Cleaning agents, air fresheners. Ensure proper ventilation during use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-Ethoxy-4-(Methoxymethyl)Phenol is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and potential damage, warranting caution.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may apply. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
2-Ethoxy-4-(Methoxymethyl)Phenol has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2018) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-Ethoxy-4-(Methoxymethyl)Phenol has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Limited data on long-term exposure.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-Ethoxy-4-(Methoxymethyl)Phenol
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on 2-Ethoxy-4-(Methoxymethyl)Phenol
Year: 2018
Conclusion: Considered safe for cosmetic use with restrictions.
View Full Report →
FDA
Report: Regulatory Status of 2-Ethoxy-4-(Methoxymethyl)Phenol
Year: 2020
Conclusion: Permitted in cosmetics; no specific restrictions.
View Full Report →
Regulatory Status
Global
2-Ethoxy-4-(Methoxymethyl)Phenol is permitted in cosmetics with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED WITH RESTRICTIONS
Concentration limits apply
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should test for reactions.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a dermatologist if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:04:01.027385Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.