7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Antioxidant · Preservative · Fragrance ingredient · Skin conditioning agent
2-Methoxy-4-Prop-1-Enylphenol
Molecular Formula
C10H12O2
Molecular Weight
164.20 g/mol
Category
Phenolic compound
Bottom Line: 2-Methoxy-4-Prop-1-Enylphenol is generally considered safe in cosmetics and food, though caution is advised with sensitive skin.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Ingested as part of food products within regulatory limits
- Not applied to broken or irritated skin
- Used by individuals without known allergies to phenolic compounds
⚠ Use with Awareness If:
- You have sensitive skin or a history of allergies
- Using multiple products containing phenolic compounds
- Pregnant or breastfeeding, consult a healthcare provider
- Experiencing skin irritation or adverse reactions
✕ Avoid If:
- You are allergic to phenolic compounds
- Using on open wounds or severely irritated skin
- Ingesting in large amounts outside of food products
- Using in combination with other irritants
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H12O2 |
| Molecular Weight | 164.20 g/mol |
| Melting Point | -10.0°C |
| Boiling Point | 125.0°C |
| Solubility | soluble (in ethanol) |
| Density | 1.08 g/cm³ |
| Log P | 2.6 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, preservatives. Considered safe in food at regulated levels.
Pharmaceutical
Topical treatments, antiseptics. Use under medical supervision for therapeutic applications.
Supplement
Herbal extracts, nutritional supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-Methoxy-4-Prop-1-Enylphenol is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 2-Methoxy-4-Prop-1-Enylphenol may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with 2-Methoxy-4-Prop-1-Enylphenol can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased risk of adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated, but health status should be considered.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children may increase risk. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
Toxicology Data
3 Endpoints
2-Methoxy-4-Prop-1-Enylphenol has low toxicity and is used in various products. Safety assessments support its use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization reactions | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-Methoxy-4-Prop-1-Enylphenol has low toxicity and is used in various products. Safety assessments support its use.
- Low acute toxicity observed in studies.
- Used safely in cosmetics and food products.
- Regulatory reviews indicate acceptable safety profiles.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-Methoxy-4-Prop-1-Enylphenol
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on 2-Methoxy-4-Prop-1-Enylphenol
Year: 2018
Conclusion: Acceptable daily intake established; safe in food applications.
View Full Report →
FDA
Report: Regulatory Status of 2-Methoxy-4-Prop-1-Enylphenol
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 73; maximum: b) 0,02 %; applies to: (a) Oral products (b) Other products Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 73)
Annex III entry 73; maximum: b) 0,02 %; applies to: (a) Oral products (b) Other products
US
FDAPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use in cosmetics, but patch test recommended for sensitive individuals.
Yes, it is considered safe in food products at regulated levels, but avoid excessive consumption.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:08:43.980656Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:31:15.069407+00:00 | 7.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.