ISS 5.5 (C) — expert assessment, full evaluation in progress. The scores in the profile below were generated before this assessment.
5.5
ISS Score
C — Moderate caution — review exposure context
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · intermediate · potential antimicrobial agent
1-Methyl-4-Prop-1-En-2-Ylcyclohexene
Molecular Formula
C10H16
Molecular Weight
136.23 g/mol
Category
chemical compound
Bottom Line: 1-Methyl-4-Prop-1-En-2-Ylcyclohexene is generally considered safe in cosmetics and food, though caution is advised with sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic formulations
- properly diluted in food applications
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- applying to children or pregnant individuals
- exposed to high temperatures during use
✕ Avoid If:
- you have a known allergy to similar compounds
- using in high concentrations without guidance
- applying to open wounds or irritated skin
- using in poorly ventilated spaces
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H16 |
| Molecular Weight | 136.23 g/mol |
| Melting Point | -74.3°C |
| Solubility | 0.0138 mg/mL at 25 °C |
| Log P | 3.4 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food additives. Generally safe when used as a flavoring agent.
Pharmaceutical
Topical treatments, medicated creams. Consult a healthcare provider for use in medications.
Household
Cleaning products, air fresheners. Ensure good ventilation when using household products.
Supplement
Dietary supplements. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 1-Methyl-4-Prop-1-En-2-Ylcyclohexene is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to increased risk.
- pregnant — Potential risks during pregnancy due to limited data.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with appropriate precautions.
- elderly — Typically low to moderate risk, but sensitivity may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but caution is advised with prolonged exposure. |
| pregnant | Moderate | Limited data on effects during pregnancy; potential risks should be considered. |
| infants_children | Very High | Children may be more sensitive to chemical exposures; higher risk of adverse effects. |
| breastfeeding | Moderate | Potential for transfer through breast milk; limited data available. |
| elderly | Low to Moderate | Elderly individuals may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
1-Methyl-4-Prop-1-En-2-Ylcyclohexene has been evaluated for safety in cosmetics and food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | EFSA Opinion (2016) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-Methyl-4-Prop-1-En-2-Ylcyclohexene has been evaluated for safety in cosmetics and food applications.
- Considered safe in low concentrations.
- Potential irritant for sensitive skin.
- Regulatory assessments vary by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 1-Methyl-4-Prop-1-En-2-Ylcyclohexene
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on 1-Methyl-4-Prop-1-En-2-Ylcyclohexene
Year: 2016
Conclusion: Acceptable daily intake established for food use.
View Full Report →
FDA
Report: Regulatory Status of 1-Methyl-4-Prop-1-En-2-Ylcyclohexene
Year: 2020
Conclusion: Permitted for use in food and cosmetics under specific conditions.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 88; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 88)
Annex III entry 88; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use
United States
FDAPERMITTED
Use in cosmetics and food under specified conditions.
United Kingdom
UK GovernmentPERMITTED
Regulated under UK REACH.
Canada
Health CanadaPERMITTED
Allowed in cosmetics and food products.
Frequently Asked Questions
It may cause irritation for sensitive skin; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Regulatory limits vary by region; generally permitted in cosmetics and food under specific conditions.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:38:07.365807Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:31:14.244321+00:00 | 6.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.