9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · aromatic compound · flavoring agent
1,2-Dimethoxy-4-Prop-1-Enylbenzene
Molecular Formula
C11H14O2
Molecular Weight
178.23 g/mol
Category
chemical compound
Bottom Line: 1,2-Dimethoxy-4-Prop-1-Enylbenzene is generally considered safe in cosmetics and food, though caution is advised with high concentrations.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Ingested as part of food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using products containing this ingredient for the first time
✕ Avoid If:
- Pregnant or breastfeeding without consulting a healthcare provider
- You have a known allergy to similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H14O2 |
| Molecular Weight | 178.23 g/mol |
| Solubility | soluble (in ethanol) |
| Log P | 2.5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, scented lotions. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, food additives. Safe for consumption within established limits.
Pharmaceutical
Topical medications, prescription creams. Use under medical supervision for therapeutic applications.
Supplement
Herbal supplements, dietary aids. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
1,2-Dimethoxy-4-Prop-1-Enylbenzene is generally safe for skin contact, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: Low
Eye contact may cause mild irritation, but serious effects are unlikely.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited safety data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse effects.
- elderly — Generally well tolerated, but individual responses may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, with low risk of adverse effects. |
| pregnant | Moderate | Limited data on safety during pregnancy; potential risks should be considered. |
| infants_children | High | Children may be more sensitive to chemical exposures; higher risk of adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
1,2-Dimethoxy-4-Prop-1-Enylbenzene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization potential | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1,2-Dimethoxy-4-Prop-1-Enylbenzene has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Generally recognized as safe in regulated uses.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 1,2-Dimethoxy-4-Prop-1-Enylbenzene
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on 1,2-Dimethoxy-4-Prop-1-Enylbenzene
Year: 2020
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of 1,2-Dimethoxy-4-Prop-1-Enylbenzene
Year: 2022
Conclusion: Permitted for use in food and cosmetics under specific regulations.
View Full Report →
Regulatory Status
Global
1,2-Dimethoxy-4-Prop-1-Enylbenzene is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, it is considered safe for skin use in cosmetics at regulated concentrations.
Yes, it is typically safe for consumption in food products within established limits.
While generally safe, some individuals may experience allergic reactions; consult a healthcare provider if unsure.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:26:35.200116Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.