9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative
Trimethyl-Pentylcyclopentanone
Molecular Formula
C13H24O
Molecular Weight
196.33 g/mol
Category
fragrance
Bottom Line: Trimethyl-Pentylcyclopentanone is generally considered safe in cosmetics and household products, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- applied in recommended concentrations
- not used on broken skin
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using multiple products containing fragrances
- applying to areas with compromised skin
✕ Avoid If:
- you are pregnant or breastfeeding without consulting a doctor
- you have a known allergy to similar fragrance compounds
- you experience irritation or adverse reactions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H24O |
| Molecular Weight | 196.33 g/mol |
| Log P | 4.2 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in moderation and patch test for sensitivities.
Household
Air fresheners, cleaning products. Ensure proper ventilation when using products.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for medicinal use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Trimethyl-Pentylcyclopentanone is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Trimethyl-Pentylcyclopentanone may lead to gastrointestinal discomfort and other adverse effects.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause respiratory irritation, particularly in high concentrations.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
- sensitive_skin — Increased risk of irritation for those with sensitive skin.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but monitor for sensitivity.
- breastfeeding — Use with caution; limited data available.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally, adults can tolerate Trimethyl-Pentylcyclopentanone with minimal adverse effects. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures; higher risk of irritation. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but sensitivity may increase with age. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Trimethyl-Pentylcyclopentanone has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2018) |
| Sensitization | non-sensitizing | Human repeated insult patch test | No sensitization observed | FDA Report (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Trimethyl-Pentylcyclopentanone has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Generally recognized as safe in cosmetic formulations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 10%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetics with proper labeling.
View Full Report →
FDA
Report: Fragrance Ingredients in Cosmetics
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Trimethyl-Pentylcyclopentanone is permitted for use in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
It is commonly found in perfumes, lotions, and household cleaners.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:19:14.108633Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.