7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aroma compound · flavoring agent
3-(P-Cumenyl)-2-Methylpropionaldehyde
Molecular Formula
C14H20O
Molecular Weight
204.31 g/mol
Category
fragrance
Bottom Line: Generally regarded as safe when used in low concentrations, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in cosmetic formulations at recommended concentrations
- In food products within established limits
- Not applied to broken skin or mucous membranes
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other fragrances
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to fragrance compounds
- Using on irritated or damaged skin
- Ingesting in large amounts
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H20O |
| Molecular Weight | 204.31 g/mol |
| Log P | 3.8 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in moderation to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe in food at regulated levels.
Supplement
Flavored supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 3-(P-Cumenyl)-2-Methylpropionaldehyde is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known allergies. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
3-(P-Cumenyl)-2-Methylpropionaldehyde is a fragrance compound with moderate safety data.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2019) |
| Sensitization | Not a sensitizer | Human repeated insult patch test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
3-(P-Cumenyl)-2-Methylpropionaldehyde is a fragrance compound with moderate safety data.
- Used in cosmetics and food products
- Potential irritant for sensitive individuals
- Regulatory assessments indicate safe use in low concentrations
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring
Year: 2018
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
SCCS
Report: Opinion on Fragrance Substances
Year: 2019
Conclusion: Safe for use in cosmetics with restrictions on concentration.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted with some restrictions in cosmetics. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Max 1% in cosmetics
UK
UK GovernmentRESTRICTED
Max 1% in cosmetics
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin in low concentrations, though some may experience irritation.
Yes, it is permitted in food at regulated levels, but moderation is advised.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:29:36.029560Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.