6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
Cis-3-Hexenyl Methyl Carbonate
Molecular Formula
C8H14O3
Molecular Weight
158.19 g/mol
Category
chemical compound
Bottom Line: Cis-3-Hexenyl Methyl Carbonate is generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C8H14O3 |
| Molecular Weight | 158.19 g/mol |
| Log P | 2.3 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, beverages. Considered safe for use in food flavoring at regulated levels.
Pharmaceutical
Topical medications, oral formulations. Use in pharmaceuticals should follow regulatory guidelines.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cis-3-Hexenyl Methyl Carbonate is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause mild gastrointestinal discomfort; however, data is limited.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but high concentrations may cause irritation.
ocular
ocular
Risk Level: Very Low
Eye contact may cause mild irritation, but significant effects are unlikely.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for cosmetic ingredients. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
Cis-3-Hexenyl Methyl Carbonate has been assessed for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cis-3-Hexenyl Methyl Carbonate has been assessed for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Generally recognized as safe in food applications.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cis-3-Hexenyl Methyl Carbonate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on Cis-3-Hexenyl Methyl Carbonate
Year: 2018
Conclusion: Considered safe for use as a food flavoring substance.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: Permitted for use in food applications.
View Full Report →
Regulatory Status
Global
Cis-3-Hexenyl Methyl Carbonate is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, yes, but individual reactions may vary. Always patch test first.
Yes, it is permitted as a flavoring agent in food applications.
Some individuals may experience irritation or allergic reactions. Use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:46:02.932985Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.