8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · masking agent · aroma enhancer
Ethyl 2,2-Dimethylhydrocinnamal
Molecular Formula
C13H18O
Molecular Weight
190.28 g/mol
Category
fragrance
Bottom Line: Ethyl 2,2-Dimethylhydrocinnamal is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- formulated in products for sensitive skin
⚠ Use with Awareness If:
- you have a history of fragrance allergies
- you are pregnant or nursing
- you are using multiple scented products
✕ Avoid If:
- you have known sensitivities to fragrances
- you experience irritation upon use
- you are using on children without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H18O |
| Molecular Weight | 190.28 g/mol |
| Log P | 3.3 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics, but may cause irritation for some.
Food
Flavoring agents, beverages. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical creams, ointments. Used in formulations; monitor for allergic reactions.
Household
Air fresheners, cleaning products. Safe in household products; avoid direct skin contact.
Supplement
Flavoring agents. Limited use in supplements; check for allergies.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Ethyl 2,2-Dimethylhydrocinnamal is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Ethyl 2,2-Dimethylhydrocinnamal may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; immediate rinsing is recommended.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; consult healthcare provider.
- sensitive_skin — Increased likelihood of skin irritation.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- breastfeeding — Generally low risk but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Ethyl 2,2-Dimethylhydrocinnamal is a fragrance ingredient with moderate safety assessments.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2015) |
| Sensitization | positive in sensitization tests | Human sensitization study | Potential allergen for sensitive individuals | EFSA Opinion (2014) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethyl 2,2-Dimethylhydrocinnamal is a fragrance ingredient with moderate safety assessments.
- Commonly used in cosmetics and food products.
- May cause allergic reactions in sensitive individuals.
- Regulatory bodies have assessed its safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethyl 2,2-Dimethylhydrocinnamal
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Ethyl 2,2-Dimethylhydrocinnamal
Year: 2015
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Ethyl 2,2-Dimethylhydrocinnamal
Year: 2014
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
Regulatory Status
Global
Ethyl 2,2-Dimethylhydrocinnamal is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
It is a fragrance ingredient commonly used in cosmetics and food products.
Generally safe, but individuals with fragrance allergies should use caution.
Yes, it may cause allergic reactions in sensitive individuals; patch testing is advised.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:25:34.892926Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.