6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · emollient · stabilizer
Allyl Cyclohexyloxyacetate
Molecular Formula
C11H18O3
Molecular Weight
198.26 g/mol
Category
chemical compound
Bottom Line: Allyl Cyclohexyloxyacetate is generally considered safe for use in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to non-broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using it in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H18O3 |
| Molecular Weight | 198.26 g/mol |
| Log P | 2.5 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Considered safe when used within food regulations.
Pharmaceutical
Topical medications, prescription creams. Use under medical supervision for therapeutic applications.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Allyl Cyclohexyloxyacetate is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause gastrointestinal irritation; moderate caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation; avoid direct exposure to eyes.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited safety data; caution is warranted.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- elderly — Generally well tolerated but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Allyl Cyclohexyloxyacetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Allyl Cyclohexyloxyacetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Allyl Cyclohexyloxyacetate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Allyl Cyclohexyloxyacetate
Year: 2018
Conclusion: Considered safe as a food flavoring agent.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: Permitted for use in food products.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 146; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 146)
Annex III entry 146; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use
US
FDAPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult a healthcare provider before using products containing this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:03:43.482170Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:31:19.593160+00:00 | 6.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.