7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · emollient · fragrance ingredient · stabilizer
Trimethyl-Propylcyclohexanepropanol
Molecular Formula
C15H30O
Molecular Weight
226.40 g/mol
Category
chemical compound
Bottom Line: Trimethyl-Propylcyclohexanepropanol is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation upon use
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H30O |
| Molecular Weight | 226.40 g/mol |
| Log P | 5.2 |
Common Use Cases
3 Categories
Cosmetic
Moisturizers, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical creams, ointments. Use as directed; consult a healthcare provider if unsure.
Household
Cleaning agents, air fresheners. Follow usage instructions; ensure good ventilation.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Trimethyl-Propylcyclohexanepropanol is generally safe for skin contact but may cause mild irritation in sensitive individuals.
oral
oral
Risk Level: Insufficient Data
Limited data on oral ingestion safety; potential for gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation may cause respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: Moderate
Eye contact may cause irritation; avoid direct exposure to eyes.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to sensitivity; avoid use.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal irritation.
- breastfeeding — Generally safe with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; monitor for skin reactions. |
| pregnant | Low to Moderate | Limited data on effects during pregnancy; caution advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse reactions. |
| breastfeeding | Low | Limited data; generally considered safe with caution. |
| elderly | Low to Moderate | Elderly may have increased sensitivity; monitor closely. |
Toxicology Data
3 Endpoints
Trimethyl-Propylcyclohexanepropanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2022) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Trimethyl-Propylcyclohexanepropanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Generally recognized as safe in cosmetic formulations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Trimethyl-Propylcyclohexanepropanol
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Trimethyl-Propylcyclohexanepropanol
Year: 2022
Conclusion: Considered safe for cosmetic use with no restrictions.
View Full Report →
FDA
Report: Regulatory Status of Trimethyl-Propylcyclohexanepropanol
Year: 2023
Conclusion: No restrictions on use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
Trimethyl-Propylcyclohexanepropanol is permitted for use in major jurisdictions with no restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:20:20.240936Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.