6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · aroma compound
Trans-Rose Ketone-3
Molecular Formula
C13H20O
Molecular Weight
192.30 g/mol
Category
fragrance
Bottom Line: Trans-Rose Ketone-3 is generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below 1%
- Formulated in products for external use only
- No known allergies to similar fragrance compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other fragrances
- Pregnant or nursing women should consult a doctor
✕ Avoid If:
- You have a known allergy to rose or similar scents
- Using on broken or irritated skin
- Ingesting in large amounts without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H20O |
| Molecular Weight | 192.30 g/mol |
| Log P | 3.4 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, soaps. Generally safe in cosmetic formulations at low concentrations.
Food
Flavoring agents, beverages. Use in food products should comply with local regulations.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for medicinal use.
Supplement
Dietary supplements. Safety in supplements is less established; consult a doctor.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Trans-Rose Ketone-3 is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Trans-Rose Ketone-3 may cause mild gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes may cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to developing systems.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated with minimal adverse effects reported. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Trans-Rose Ketone-3 has limited safety data but is generally recognized as safe in cosmetics and food.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitization | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Trans-Rose Ketone-3 has limited safety data but is generally recognized as safe in cosmetics and food.
- Used primarily for fragrance in various products
- Limited studies on long-term effects
- Regulatory assessments vary by region
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Fragrance ingredients should be used with caution due to potential sensitization.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Trans-Rose Ketone-3 is permitted in the US and UK, but restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Must comply with SCCS guidelines
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO_DATA
None
Frequently Asked Questions
It may cause irritation or allergic reactions in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products containing this ingredient during pregnancy.
Possible side effects include skin irritation and allergic reactions; use with caution.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:10:28.717863Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.