7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative
Ethyl Methylphenylglycidate
Molecular Formula
C12H14O3
Molecular Weight
206.24 g/mol
Category
fragrance
Bottom Line: Ethyl Methylphenylglycidate is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic products
- applied to intact skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- exposed to sunlight after application
✕ Avoid If:
- you are pregnant or breastfeeding
- you have a known allergy to similar compounds
- using on broken or irritated skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Boiling Point | 272.0°C |
| Solubility | Soluble (in ethanol) |
| Log P | 1.9 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, deodorants. Generally safe in cosmetics; patch test recommended.
Food
Flavoring agents, confectionery. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical creams, ointments. Use in pharmaceuticals is limited; consult a professional.
Household
Air fresheners, cleaning products. Safe in household products; use in well-ventilated areas.
Supplement
None identified. Not typically used in dietary supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Ethyl Methylphenylglycidate is generally safe for skin contact in cosmetic formulations.
oral
oral
Risk Level: Moderate
Ingestion of Ethyl Methylphenylglycidate may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but should be minimized in poorly ventilated areas.
ocular
ocular
Risk Level: High
Eye contact with Ethyl Methylphenylglycidate can cause irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to sensitivity and potential for adverse reactions.
- pregnant — Caution advised due to limited safety data.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risks.
- breastfeeding — Typically low risk but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
Toxicology Data
3 Endpoints
Ethyl Methylphenylglycidate has been evaluated for safety in cosmetics and food applications, showing moderate safety profiles.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2017) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethyl Methylphenylglycidate has been evaluated for safety in cosmetics and food applications, showing moderate safety profiles.
- Used primarily for fragrance in various products.
- Regulatory bodies have assessed its safety.
- Generally safe when used as directed.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethyl Methylphenylglycidate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Ethyl Methylphenylglycidate
Year: 2018
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Ethyl Methylphenylglycidate
Year: 2017
Conclusion: Acceptable daily intake established for food use.
View Full Report →
Regulatory Status
Global
Ethyl Methylphenylglycidate is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
It is advisable to avoid using products with this ingredient during pregnancy due to limited safety data.
This ingredient is commonly found in fragrances, lotions, and household cleaning products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:40:22.878441Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.