7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · flavoring agent · antioxidant · skin conditioning agent
Sweet Orange Oil
Also known as: Citrus sinensis oil, Orange oil
Molecular Formula
C15H22O
Molecular Weight
218.33 g/mol
Category
essential oil
Bottom Line: Sweet Orange Oil is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in diluted form for topical applications
- consumed in small amounts as a flavoring agent
- not applied to broken skin
- used in well-ventilated areas to avoid inhalation issues
⚠ Use with Awareness If:
- you have citrus allergies or sensitivities
- you are pregnant or nursing
- you are using it in high concentrations
- you have a history of skin reactions to essential oils
✕ Avoid If:
- you have a known allergy to citrus fruits
- you are applying it to sensitive areas like the eyes
- you are using it in high concentrations without dilution
- you are taking certain medications that may interact
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H22O |
| Molecular Weight | 218.33 g/mol |
| Log P | 4.8 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, body lotions, aromatherapy oils. Dilute before applying to skin to avoid irritation.
Food
Flavoring agents, beverages, confectionery. Generally safe in small amounts; check for allergies.
Pharmaceutical
Topical ointments, medicated creams. Use under guidance to avoid adverse reactions.
Supplement
Dietary supplements, essential oil capsules. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Sweet Orange Oil is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Sweet Orange Oil can be safe in small amounts, but excessive consumption may lead to gastrointestinal issues.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of Sweet Orange Oil is typically safe, but high concentrations may cause respiratory irritation.
ocular
ocular
Risk Level: High
Contact with eyes can cause irritation and discomfort; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to essential oils; potential for adverse reactions.
- pregnant — Limited data on safety during pregnancy; use with caution.
- sensitive_skin — Higher risk of irritation and allergic reactions.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated; patch testing recommended.
- breastfeeding — Use cautiously and consult a healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individuals with sensitive skin should test for reactions. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | Very High | Higher sensitivity to essential oils; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data; potential for transfer through breast milk. |
| sensitive_skin | High | Higher risk of irritation and allergic reactions. |
Toxicology Data
3 Endpoints
Sweet Orange Oil has been evaluated for safety in cosmetics and food applications, showing low toxicity and minimal irritation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Human patch test | No sensitization reactions reported | EFSA Opinion (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Sweet Orange Oil has been evaluated for safety in cosmetics and food applications, showing low toxicity and minimal irritation.
- Generally recognized as safe in food applications.
- Low irritation potential in cosmetic use.
- Requires dilution for topical applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Sweet Orange Oil
Year: 2012
Conclusion: Sweet Orange Oil is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of Sweet Orange Oil
Year: 2015
Conclusion: Sweet Orange Oil is safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: SCCS Opinion on Sweet Orange Oil
Year: 2018
Conclusion: Sweet Orange Oil is safe for use in cosmetic products with proper labeling.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 350; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use | Annex III entry 351; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 350)
Annex III entry 350; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use | Annex III entry 351; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use
US
FDAPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Sweet Orange Oil is generally safe for skin use when diluted properly, but patch testing is recommended.
Sweet Orange Oil can be ingested in small amounts as a flavoring, but consult a healthcare provider first.
If you experience a reaction, discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-20T04:09:30.564402Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:32:05.008228+00:00 | 7.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.