9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer
Methylcyclopentadecenone
Molecular Formula
C16H28O
Molecular Weight
236.39 g/mol
Category
chemical compound
Bottom Line: Methylcyclopentadecenone is generally considered safe for use in cosmetics and food, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H28O |
| Molecular Weight | 236.39 g/mol |
| Log P | 6.1 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, hair products. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Used in low concentrations; consult food safety guidelines.
Pharmaceutical
Topical medications, prescription creams. Use under medical supervision; monitor for reactions.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Methylcyclopentadecenone is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, with potential for gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally of very low concern, with minimal irritation reported.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to sensitive skin and potential for adverse reactions.
- pregnant — Moderate risk due to potential sensitivity and hormonal changes.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low irritation potential.
- breastfeeding — Generally low risk but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for cosmetic ingredients. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to certain substances. |
| infants_children | High | Infants and children have more sensitive skin and may react differently. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methylcyclopentadecenone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methylcyclopentadecenone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in animal studies.
- Generally recognized as safe in cosmetic formulations.
- Limited data on long-term effects in humans.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methylcyclopentadecenone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on Methylcyclopentadecenone
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: No objections to the use of Methylcyclopentadecenone in food products.
View Full Report →
Regulatory Status
Global
Methylcyclopentadecenone is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult a healthcare provider before using products containing this ingredient during pregnancy.
Potential side effects may include irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:46:24.939094Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.