8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · skin conditioning agent · antioxidant · preservative · stabilizer
Evernia Prunastri Extract
Category
plant extract
Bottom Line: Evernia Prunastri Extract is generally considered safe for use in cosmetics and food, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- not combined with known allergens
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or breastfeeding
- you are allergic to similar plant extracts
✕ Avoid If:
- you have a known allergy to Evernia Prunastri
- you experience irritation upon use
- you are using it in high concentrations
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrance oils, skin creams, shampoos. Generally safe in cosmetics, but patch test first.
Food
Flavoring agents, food additives. Used in food, but check for allergies.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider before use.
Supplement
Herbal supplements, dietary aids. Use with caution; consult a doctor.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Evernia Prunastri Extract is generally well-tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Evernia Prunastri Extract may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause mild respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort, requiring immediate rinsing.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to extracts may lead to adverse reactions.
- sensitive_skin — Increased likelihood of irritation and allergic reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well-tolerated with minimal adverse effects.
- pregnant — Generally low risk, but caution is advised due to limited data.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well-tolerated; however, individual sensitivities may vary. |
| pregnant | Low to Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | Moderate | Children may be more sensitive to extracts; use with caution. |
| breastfeeding | Insufficient Data | Insufficient data on effects during breastfeeding. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Evernia Prunastri Extract has low toxicity and is commonly used in cosmetics and food products.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2018) |
| Sensitization | non-sensitizing | Human patch test | No sensitization observed | EFSA Opinion (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Evernia Prunastri Extract has low toxicity and is commonly used in cosmetics and food products.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetics.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Evernia Prunastri Extract
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Evernia Prunastri Extract
Year: 2018
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on the Safety of Evernia Prunastri
Year: 2015
Conclusion: No safety concerns at typical use levels.
View Full Report →
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Annex III entry 91; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionRESTRICTED IN COSMETICS (ANNEX III, ENTRY 91)
Annex III entry 91; no maximum concentration is recorded in CosIng for this entry; check the entry's conditions of use
United States
FDAPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult your healthcare provider before using products containing this extract during pregnancy.
It is often found in fragrances, skin creams, and some food flavorings.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:49:02.007464Z | — | Initial data enrichment via 3-phase structured outputs |
| Regulatory status correction | 2026-10-29T21:31:41.877013+00:00 | 8.0 | EU regulatory status replaced with the CosIng Annex entry; the safety score was not re-evaluated. |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.