9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · masking agent · odorant · sensory enhancer
Cyclamen Aldehyde / Methyl Anthranilate Schiff Base
Molecular Formula
C21H25NO2
Molecular Weight
323.4 g/mol
Category
fragrance
Bottom Line: Cyclamen Aldehyde / Methyl Anthranilate Schiff Base is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly formulated in products
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in products for children
- exposed to high temperatures during use
✕ Avoid If:
- you are pregnant or nursing
- you have a known allergy to similar compounds
- using in products intended for ingestion without proper safety review
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C21H25NO2 |
| Molecular Weight | 323.4 g/mol |
| Log P | 5 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in well-formulated products to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe in food when used within regulatory limits.
Pharmaceutical
Topical creams, ointments. Ensure proper formulation to avoid adverse reactions.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to avoid inhalation risks.
Supplement
Flavoring in dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclamen Aldehyde is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Cyclamen Aldehyde may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children are at a higher risk of adverse effects due to their developing systems.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated by healthy adults.
- elderly — May be tolerated but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate exposure, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more susceptible to adverse effects; avoid use in this group. |
| breastfeeding | Insufficient Data | Limited information on safety during breastfeeding. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities; monitor for adverse reactions. |
Toxicology Data
3 Endpoints
Cyclamen Aldehyde / Methyl Anthranilate Schiff Base has been evaluated for safety in various applications, showing low toxicity in regulated uses.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Buehler test | No sensitization potential | EFSA Opinion (2016) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclamen Aldehyde / Methyl Anthranilate Schiff Base has been evaluated for safety in various applications, showing low toxicity in regulated uses.
- Low acute toxicity reported.
- Potential irritant for sensitive skin.
- Regulatory assessments support safe use in cosmetics and food.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclamen Aldehyde
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Cyclamen Aldehyde
Year: 2018
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Methyl Anthranilate
Year: 2016
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
Regulatory Status
Global
Cyclamen Aldehyde / Methyl Anthranilate Schiff Base is permitted in major markets with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, yes, but individuals with sensitive skin should exercise caution.
Yes, it is permitted in food applications within established safety limits.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:57:51.727467Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.