7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
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fragrance ingredient · skin conditioning agent · antioxidant · emollient
Bulnesia Sarmientoi Extract Acetylated
Category
plant extract
Bottom Line: Generally regarded as safe for topical use, though ingestion should be approached with caution based on limited data.
Quick Answer
✔ Generally Safe If:
- Used in cosmetic formulations at recommended concentrations
- Applied to intact skin
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using other active ingredients in your skincare routine
- Pregnant or breastfeeding
✕ Avoid If:
- You have known allergies to similar plant extracts
- Using on broken or irritated skin
- Ingesting without proper guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, body lotions, shampoos. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, herbal teas. Use within established food safety guidelines.
Pharmaceutical
Herbal supplements, topical ointments. Consult healthcare provider before use.
Supplement
Dietary supplements, herbal capsules. Use under professional guidance; effects vary.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Bulnesia Sarmientoi Extract Acetylated is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Bulnesia Sarmientoi Extract Acetylated may pose risks, particularly in high doses or prolonged use.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but concentrated forms may cause respiratory irritation.
ocular
ocular
Risk Level: High
Eye contact with Bulnesia Sarmientoi Extract Acetylated can lead to significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to adverse effects.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Low to moderate risk, but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; potential risks should be considered. |
| infants_children | Very High | Higher sensitivity in infants and children may lead to adverse effects. |
| breastfeeding | Moderate | Limited information on excretion in breast milk; caution is advised. |
| elderly | Low to Moderate | Elderly individuals may have increased sensitivity to extracts. |
Toxicology Data
3 Endpoints
Research indicates Bulnesia Sarmientoi Extract Acetylated is generally safe for topical use, with limited data on ingestion.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2020) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates Bulnesia Sarmientoi Extract Acetylated is generally safe for topical use, with limited data on ingestion.
- Topical applications show low irritation potential
- Limited studies on oral toxicity
- Potential allergenic reactions noted in sensitive individuals
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Bulnesia Sarmientoi Extract
Year: 2020
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Bulnesia Sarmientoi Extract
Year: 2021
Conclusion: Insufficient data to determine safety for food use; further studies needed.
View Full Report →
FDA
Report: Regulatory Status of Bulnesia Sarmientoi Extract
Year: 2022
Conclusion: Generally recognized as safe for topical use; ingestion not established.
View Full Report →
Regulatory Status
Global
Generally recognized as safe for topical use; ingestion safety remains unclear. Switch to Detailed mode for full regulatory breakdown.
United States
FDAGENERALLY RECOGNIZED AS SAFE FOR TOPICAL USE
Ingestion not established
European Union
European CommissionUNDER REVIEW FOR FOOD USE
Limited data available
United Kingdom
UK GovernmentGENERALLY RECOGNIZED AS SAFE FOR TOPICAL USE
Ingestion not established
Canada
Health CanadaNO DATA AVAILABLE
N/A
Frequently Asked Questions
Generally safe for most skin types, though patch testing is recommended for sensitive skin.
Ingestion is not well-studied; consult a healthcare provider before use.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:32:13.648770Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.