7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · fixative
Methylcyclohexenylpropyl-Cyclopentanone
Molecular Formula
C15H24O
Molecular Weight
220.35 g/mol
Category
fragrance ingredient
Bottom Line: Methylcyclohexenylpropyl-Cyclopentanone is generally considered safe in cosmetics, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly formulated in products
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have a history of allergies
✕ Avoid If:
- you are allergic to fragrance ingredients
- you experience irritation upon use
- you have respiratory issues
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24O |
| Molecular Weight | 220.35 g/mol |
| Log P | 3.4 |
Common Use Cases
3 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in well-formulated products to minimize irritation risk.
Pharmaceutical
Topical creams, ointments. Ensure proper formulation to avoid adverse reactions.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to reduce inhalation risks.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Methylcyclohexenylpropyl-Cyclopentanone is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; caution is advised, especially in children.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but prolonged exposure may cause respiratory irritation.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; immediate rinsing is recommended.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated by healthy adults.
- elderly — Generally well tolerated, but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate exposure without significant issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methylcyclohexenylpropyl-Cyclopentanone is a fragrance ingredient with moderate safety data available.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| Skin Irritation | non-irritating | Human patch test | Low concern for irritation | CIR Safety Assessment (2015) |
| Sensitization | positive in sensitization tests | Human sensitization study | Moderate concern for sensitization | SCCS Opinion (2018) |
| LD50 Oral | not established | Not available | Insufficient data for acute toxicity | FDA Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methylcyclohexenylpropyl-Cyclopentanone is a fragrance ingredient with moderate safety data available.
- Used widely in cosmetics and household products.
- Potential for skin sensitization in some individuals.
- Regulatory assessments indicate varying safety profiles.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe when used as intended in cosmetics.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Requires further evaluation for sensitization potential.
View Full Report →
FDA
Report: Fragrance Ingredient Safety
Year: 2020
Conclusion: Generally recognized as safe for use in cosmetics.
View Full Report →
Regulatory Status
Global
Methylcyclohexenylpropyl-Cyclopentanone is permitted in the US and UK, but restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Use limited to specific concentrations in cosmetics.
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
No specific regulations identified.
Frequently Asked Questions
It may cause irritation or allergic reactions in sensitive individuals, so caution is advised.
It is often found in perfumes, lotions, and household cleaning products.
Yes, the EU restricts its concentration in cosmetics to 0.5% due to sensitization concerns.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:44:27.579856Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.