10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · stabilizer · emollient
4-T-Butylcyclohexanol
Molecular Formula
C10H20O
Molecular Weight
156.26 g/mol
Category
chemical compound
Bottom Line: 4-T-Butylcyclohexanol is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- applied in recommended concentrations
- not used on broken skin
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you experience irritation or allergic reactions
- you are using products with conflicting ingredients
- you have a known sensitivity to similar compounds
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H20O |
| Molecular Weight | 156.26 g/mol |
| Log P | 3 |
Common Use Cases
3 Categories
Cosmetic
Moisturizers, sunscreens, hair conditioners. Generally safe in cosmetic formulations when used as directed.
Pharmaceutical
Topical creams, ointments. Use in pharmaceuticals is regulated; follow medical advice.
Household
Cleaning agents, air fresheners. Use in household products should follow label instructions.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 4-T-Butylcyclohexanol is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 4-T-Butylcyclohexanol may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with 4-T-Butylcyclohexanol may cause irritation, thus moderate risk is noted.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
- pregnant — Potential risks to fetal development warrant caution.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Typically low risk but should be cautious.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally, adults can tolerate exposure to 4-T-Butylcyclohexanol without significant issues. |
| pregnant | Moderate | Pregnant individuals should limit exposure due to potential risks to fetal development. |
| infants_children | High | Infants and children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Elderly individuals typically have a lower risk but should still exercise caution. |
Toxicology Data
3 Endpoints
4-T-Butylcyclohexanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Draize test | Not irritating | SCCS Opinion (2016) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Status (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
4-T-Butylcyclohexanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetic formulations.
- Limited data on long-term exposure effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 4-T-Butylcyclohexanol
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on 4-T-Butylcyclohexanol
Year: 2016
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
FDA
Report: Regulatory Status of 4-T-Butylcyclohexanol
Year: 2020
Conclusion: No restrictions on use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
4-T-Butylcyclohexanol is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test products containing this ingredient.
Consult with a healthcare provider before using products containing this ingredient during pregnancy.
It is commonly found in moisturizers, sunscreens, and household cleaning products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:37:45.750345Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.