Nuit De Issara Mikai
EDP Spray

Fragrance Notes

GrapefruitLeatherPatchouliPink PepperTonka BeanTonka Bean and PatchouliVanilla
MenPerfume OilWoody Spicy

CA Perfume

Nuit De Issara Mikai

Inspired by Issey Miyake · Format: EDP Spray

Format
A-
HumanSafe Verified ✓
37 Ingredients Assessed
Generally Safe
73th percentile · No allergens flagged

Safe for everyday use. This product is suitable for most adults in normal fragrance application.

No Banned SubstancesEDP Leave-On Format
Product Safety Score
7.3 / 10
PSSDose-aware safety at actual concentration
Mood Elevation Index™
6.1 / 10
MEI™Serene mood profile
Environmental Safety
ESSEnvironmental assessment
Evidence Quality
CSSConfidence in evidence base
Buy on CA Perfume →Full Report — Join Free

Why This Score

✔Primary ingredient Tetramethyl Acetyloctahydronaphthalenes (20.0%) carries a solid ISS safety score of 6.5/10, supporting the product's Grade B overall safety profile.
✔Dimethyl-4-Isoheptenal Dimethyl Acetal (5.0%) scores well at ISS 8.0/10, indicating favorable safety data for this woody component.
⚠As with all eau de parfum products, apply to skin in moderation and avoid contact with eyes. Individuals with sensitive skin or fragrance allergies should perform a patch test before regular use.

Scores are calculated by HumanSafe™ — an independent third-party platform — using peer-reviewed toxicology sources, regulatory databases, and HumanSafe's Mood Architecture™.

Safety at a Glance

✅ Safe for

  • —Daily topical use
  • —Most healthy adults
  • —Long-term skin contact
  • —EDP leave-on format

⚠ Use with care if

  • —Sensitive or reactive skin
  • —Direct eye-area contact

✕ Avoid if

  • —Broken or compromised skin
  • —Children under 3 years
Bottom line: Nuit D'issey is a woody-spicy eau de parfum with a Grade B safety rating (PSS 6.8/10). The formula's top ingredients have acceptable safety profiles, though standard fragrance precautions—patch testing and avoiding eye contact—should be observed.

Full breakdown available to members. Join free →

Key Factors

Score Drivers
01 / INGREDIENT SAFETY
Formulation Quality
Dose-aware ingredient safety at actual use concentration. 30 ingredients assessed using SCCS opinions, ECHA REACH dossiers, and primary literature.
PSS 7.3
02 / ENVIRONMENTAL
Environmental Safety
Environmental impact at full formulation level — sourcing, biodegradability, and persistence in aquatic systems assessed per REACH and ECHA criteria.
Members only
03 / EVIDENCE QUALITY
Data Confidence
Confidence Substantiation Score — weighted evidence quality from clinical RCTs (A), observational studies (B), expert consensus (C). Higher CSS = more reliable scores.
Members only

Ingredients

37 Total
CAS No.INCI NameFUNCTIONISSStatus
64-17-5Alcohol Denat.Solvent / Carrier7.0A-Moderate
7732-18-5AquaSolvent / Carrier10.0A+Low Risk
54464-57-2Tetramethyl AcetyloctahydronaphthalenesFragrance ingredient7.0A-Moderate
111879-80-2(12e)-1-Oxacyclohexadec-12-En-2-OneFragrance ingredient7.0A-Moderate
5989-27-5D-LimoneneFragrance ingredient5.5C
expert assessment, full evaluation in progress
High Concern

32 more ingredients in this formulation

See Full Ingredient List — Join Free →

Ingredients sourced from MG Safety Data Sheet and EU Allergen Certificate. Formulation: fragrance oil 20% + Ethanol 65% + Aqua 15%. ⚑ = EU regulated allergen (Regulation EC 1223/2009). Note 1 = Annex II prohibited substance. Note 2 = commercial quality (includes both isomers).

Fragrance Mood Profile

MEI™ Mood Architecture
Mood Elevation
Index™
6.1
MEI™
Primary Mood
Serene
Secondary Mood
Romantic
Inner Voice
I am enough.
CONFIDENCE
5.8
MOOD LIFT
6.7
WARMTH
6.9
ENERGY
2.8
PRESENCE
6.2
IDENTITY
6.3
SOCIAL EASE
5.8

MEI™ scores are calculated by HumanSafe™ using HumanSafe's Mood Architecture™ — a 9-dimension olfactory-emotion mapping system. MEI is an intensity scale: 3/10 = subtle, 9/10 = immersive. Score reflects mood character, not safety.

Usage & Safety Guidance

How to Use
Apply to pulse points — wrists, neck, inner elbow. For Duo Set: oil first, then EDP spray over for superior fixation.
Frequency
Safe for daily use at normal application volumes for healthy adults.
Storage
Room temperature, away from sunlight. Shelf life: 24 months unopened, 12 months after first use.
When to Avoid
Known fragrance allergy. Broken or irritated skin. Children under 3 years.

Safer Alternatives

Higher PSS Score

Products with higher Product Safety Scores. Independently assessed by HumanSafe™.

Joy Loop

CA Perfume

Joy Loop

PSS 8.6MEI 6.390
View Assessment →
Red Musk

CA Perfume

Red Musk

PSS 8.3MEI 7.760
View Assessment →
Sisi Rose Signature

CA Perfume

Sisi Rose Signature

PSS 8.2MEI 5.290
View Assessment →
White Musk

CA Perfume

White Musk

PSS 8.2MEI 7.470
View Assessment →

Frequently Asked Questions

Is Nuit D'issey safe for daily use?+

Yes, Nuit D'issey carries a Grade B PSS score, indicating it is generally safe for regular fragrance use. However, daily application should follow standard fragrance practices: apply sparingly to pulse points, avoid direct eye contact, and discontinue use if skin irritation develops. Individuals with known fragrance sensitivities should patch-test first.

Are there any ingredients I should watch out for?+

The formula's primary ingredients all carry moderate-to-strong safety scores (ISS 6.0–8.0/10). No individual ingredient stands out as a major concern. However, as with any fragrance, some people may experience sensitivity or allergic reactions depending on personal skin chemistry. If you have a history of fragrance allergies or very sensitive skin, introduce this product gradually.

What does a PSS of 6.8/10 (Grade B) mean?+

The PSS (Product Safety Score) is an independent safety assessment rated on a scale of 0–10, with Grade B representing above-average safety for cosmetic fragrances. This score reflects the concentration and safety data of the product's key ingredients. A Grade B indicates the product is safe for intended use when used as directed, though it is not rated in the highest safety tier.

The HumanSafe™ Difference

Most safety tools rate ingredients in isolation — one score regardless of concentration, context, or how the product is used. We assess at actual use concentration.

DimensionOther Apps (EWG, Yuka)HumanSafe™
Dose awarenessSame score regardless of concentrationAssessed at actual use concentration in this product
Exposure contextSame score for rinse-off and leave-on productsAdjusted for product format and absorption rate
AllergensBinary flag — present or absentConcentration compared to IFRA/EU safe limits
Purchase signalScore only, no recommendationClear verdict + safer alternatives ranked by PSS

Version & Audit Trail

Last Updated
April 2026
Scoring Model
PSS v4.1
Data Pipeline
v3.3.2
Status
✓ Verified
VersionDatePSS ScoreISS (avg)Change Summary
v2.1.0April 20267.3—Current assessment — PSS v4.1 route-weighted engine. Dose-aware scoring at actual use concentration.
Safety DocumentsSource doc: 2026-04-13
Safety Data Sheet — EDPCA PS 0768
Available
Download PDF
Safety Data Sheet — OilCA PO 0768
Available
Download PDF
IFRA CertificateCA-0768
Available
Download PDF
Allergen Declaration — EDPCA PS 0768
Available
Download PDF
Allergen Declaration — OilCA PO 0768
Available
Download PDF
Safety Data Sheets are prepared by EMRA LLC for CA Perfume, based on the supplier safety data sheet on file for each fragrance. IFRA and Allergen certificates are original supplier documents on file.
HumanSafe™ is an independent third-party platform. This evaluation is not affiliated with the brand or manufacturer. Scores reflect HumanSafe's proprietary PSS methodology — Ingredient Safety (ISS), Environmental Safety (ESS), and Confidence Substantiation (CSS) — and HumanSafe's Mood Elevation Index™ (MEI™). All scores on a 0–10 display scale. Evidence grades: A=RCT · B=Observational · C=Expert consensus.